ympb121an hour ago
It may be a dumb reason to do it, but recently I've started to focus on my health a bit more because of news like this (more exercise and healthier food).
The thinking is, if we find a way to massively extend the human lifespan/reverse aging I want to live long enough for that.
I'd be pissed if we as humanity solved aging and I die just before that, not taking any chances.
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kcarter8041 minutes ago
Seems like you are interested in living longer. One cool trick to doing that has always been to focus on your health. Are you saying that before recent developments the extension of life benefit wasn't worth it for you? By the way, when you die it's impossible to be "pissed".
easygenes26 minutes ago
Maybe they mean the compromises they're making didn't weigh out enough to be motivating over the thought of just a few more years, but if those few years might make the difference to catching an opportunity for double or more the years it's suddenly motivating enough.
androiddrewan hour ago
lol, I am kind of in the same mode of thought but just kind of expect it not to happen.
There was a really shitty movie starring Jared Leto I think about the same problem. Being the last guy to miss out on being immortal
smotchedan hour ago
Mr. Nobody is not a bad movie!
inshard2 hours ago
Slightly tangential: Michael Levin’s work on bioelectricity and cell reprogramming is pretty interesting in context of emergent behaviors in groups of cells. https://en.wikipedia.org/wiki/Michael_Levin_(biologist)
taneqan hour ago
Sounds like the immortal jellyfish solution. We squeeze entropy out of our DNA by creating a new fresh cell (ovum) that’s very sensitive to genetic defects, meaning if it survives it’s probably good. The jellyfish just shrinks back to a single cell (presumably with some mechanism for keeping the ‘best’ cell) to reset the damage. This is doing the same thing, but piece by piece.
Edit: And wow, that abstract appears to have eaten an entire thesaurus.
bitwizean hour ago
Because this is the worst timeline, we're getting cell reprogramming used to grow artificial brains to run AI workloads before functional aging remediation... let alone GTA VI.
layer83 hours ago
If something like this ever becomes a practical application on the organismal level, the octogenarian dictators of the world will rejoice.
mullingitoveran hour ago
An individual pancreas cell discovering the secret to immortality is a triumph for that cell, and a real bad thing for the body. This is like that, but for the entire human population.
skissanean hour ago
Even if medical science one day eliminates aging and disease, nobody is going to live forever—eventually you’ll succumb to an accident, or war, or homicide.
robwwilliamsan hour ago
Not to mention the two leading septuagenarian dictators: Putin and Xi.
malloryerikan hour ago
Putin keeps talking about living forever, which makes his nuclear threats a bit less worrisome.
neoman hour ago
If you're listening just covered this the other day, they did a good job, worth a watch: https://www.youtube.com/watch?v=tQFE_3Mr4yQ (If you're listening is generally pretty good)
moralestapia3 hours ago
To expand, we might find out the hard way that having an expiration date was a feature of our species, not a flaw.
card_zeroan hour ago
Walk me through it: in order to get dictators killed, because they defend themselves very effectively, we should put everybody on the planet under a biological death sentence, which will get the dictators too.
No, I cannot endorse this.
setran hour ago
Science moves forward one death at a time
So at least two systems run better with the implicit time limit.
card_zeroan hour ago
We should kill the dictators deliberately, improve our biology deliberately, and get stuffy old people like me to change their minds deliberately. No stupid use of death as a proxy, it's a horribly blunt instrument. "Let your ideas die in your place".
Besides, maybe it's the young people who are the most dogmatic. Studies are inconclusive: https://en.wikipedia.org/wiki/Planck%27s_principle#Rebuttal If we're going to go around killing people for having rigid ideas, perhaps concentrate on the young ones, for statistical reasons.
mullingitover30 minutes ago
It's a feature of every species that evolves. You can't evolve if you're striving to outcompete your offspring. You quickly game out that not having offspring is the winning chess move there. Now you're not having offspring, and thus you're not evolving. Then the environment changes and you, being unable to adapt in any way, go extinct.
robwwilliamsan hour ago
Definitely a feature: Disposable soma theory of Kirkwood. Your germline is the real “you”.
bloqsan hour ago
Neurogenesis slows for a similar reason
suslik2 hours ago
Of course it's a feature; it still doesn't mean it cannot be stopped or considerably postponed.
TedDoesntTalk2 hours ago
I’m always fascinated by people who think death can be “stopped” (not postponed, but eliminated). Fascinating.
suslik2 hours ago
Is there a reason why it can't possibly be stopped?
TedDoesntTalkan hour ago
Everything we have witnessed that arises also passes away. Every living thing, every dead thing - even stars and planets - arise and pass away.
I feel it’s the ultimate hubris to think we can cheat death.
Moreover, why would you want immortality?
Many books of fiction and poetry discuss the curse of immortality.
Here are a few:
The Immortal, Jorge Luis Borges (1947)
A man discovers a source of immortality, but eternity eventually destroys the significance of individual experiences. When everything can happen infinitely, nothing feels particularly important.
The Mortal Immortal — Mary Shelley (1833) - also wrote Frankenstein
A man drinks an elixir and lives for centuries without substantially aging. He watches his wife grow old and die, and becomes increasingly alienated from humanity. Shelley focuses on loneliness and the psychological weight of endless time.
All Men Are Mortal — Simone de Beauvoir (1946)
An immortal man lives through centuries of history, relationships, and political upheaval. Gradually he discovers that even extraordinary achievements seem meaningless when time is unlimited.
The Makropulos Affair — Karel Čapek (1922)
A woman lives more than 300 years through an elixir. She retains her youth but becomes emotionally exhausted, cynical, and incapable of finding pleasure.
—
There are more. Sure, these are fiction. But use your imagination. Why would you want immortality, even if you could retain perfect health indefinitely?
ribosometronome18 minutes ago
Why would someone want to live 100 years? 80? 60? 40? 20? Were ultimately just saying we like living and would like to keep living until we decide we don’t want to anymore. The thought that people might like living longer than they get is pretty well supported by every dying person who doesn’t want to die rather than just some speculative fiction.
snkan hour ago
Not everything; only 93% of humans have died, for example. Past != future.
Nursie43 minutes ago
Because one lifetime is not enough to experience everything the world has to offer.
If one doesn't have to watch ones spouse, friends and family grow old and die, because it is available widely, that removes some of your objections.
Personally I don't subscribe to the idea that things lose meaning in a longer life, I find it a 'just so' story of self comfort in the face of the inevitable.
jojobasan hour ago
Well if one can live to the heat death of the universe I'll count it as prevented, not postponed, death.
card_zeroan hour ago
That is a really wanky, lazy, cliched, annoying trope - to a longevity advocate, of course. For the many people who inexplicably think death is friendly and wonderful, these tired old storylines are utterly insightful. (see also: Doctor Who, they did stories about immortality-seeking villains a few times.)
card_zeroan hour ago
Well, accidents. Inconveniently close supernovas. Something is likely to get you eventually, some few millennia later.
shrubblean hour ago
All it would take would be one billionaire who invested in long term bonds, à la Hitchhikers Guide to the Galaxy…
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dyauspitr2 hours ago
That’s a coping mechanism because we can’t change it.
hootz2 hours ago
Wasn't death a requirement for us to reach this current stage of human evolution? I don't think it is a good idea to stop it entirely.
jeremyjh2 hours ago
Evolution of humans by natural selection is already over with - or at least proceeding at time scales irrelevant to our civilization.
card_zeroan hour ago
"Contrary to popular belief," https://en.wikipedia.org/wiki/Recent_human_evolution
I don't think it matters, mind you.
snkan hour ago
If it doesn't matter then it is not evolution, right?
card_zero30 minutes ago
So it's things like: some people died because there was a famine and they didn't have lactose tolerance (and thus didn't have any cows, or they'd just eat the cows, a detail). Some people died due to having unnecessarily large and sturdy jaws in the era of cooked food. (Not sure how this would cause death, perhaps due to greater surface area for tooth trouble? It's always the teeth.) Then, their offspring - wait, I mean other people's offspring - are more adapted and less vulnerable.
Well sure, we should become less vulnerable, including biologically. But there are better ways to accomplish this than having people killed.
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bravoetchan hour ago
Not sure about death being required. It's more that life after reproductive success is not required.
robwwilliams40 minutes ago
…that longer life after reproductive exhaustion is not under selection.”
idle_zealotan hour ago
Curing aging doesn't stop death entirely. There's still the attrition of living in the physical world. Some portion of the population will trip and break their necks every year.
LoganDark2 hours ago
Indeed; the biggest reason is surely cancer.
lilycarranza9992 hours ago
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torben-friis2 hours ago
Eh, we might see some benefit to leaders having a reason to care about stuff 10+ years from now.
Waterluvianan hour ago
I feel like AI has opened a door of plausibility to Black Mirror or Twilight Zone concepts more than any other novel technology in my lifetime.
What if living 300 years meant the entire tempo of human living changes. That we all just slow right down because having control over our aging and when it happens. To be able to decide to extend your 20s… or not. To spend decades in your 30s. How would that change what’s important to us?
axus2 hours ago
That'll be the commoners' problem; they'll be planning out how to survive the next 300 years.
deadbabe2 hours ago
They cannot survive the next 300 years unless we all survive the next 300 years. A dictator is motivated by having power over others, not being some lone survivalist fending for himself in nature.
EA-31672 hours ago
I’d be far more worried about this causing turbo cancer than immortality in dictators.
King-Aaron2 hours ago
It might be beneficial if it gives turbo cancer to the dictators, of course.
bitwizean hour ago
It turns out that if you trigger all four Yamanaka factors—yeah, turbo cancer. But if you trigger only three of the four, you can trigger a reversion to the stem cell state without the increased cancer risk.
robwwilliamsan hour ago
Dubious. Do you have a reference or two? In general biological systems are not this simple.
deadbabe2 hours ago
What if we cure cancer with AI very soon? Give it 10 years.
vibrio44 minutes ago
Remind me of the chance some same AI kills us all before 10 years?
EA-316729 minutes ago
Funny you mention that, I guess this is a new cult maxim for the faithful?
https://fixvx.com/Kalshi/status/2109791302674235656?s=20
Save us all from people like this.
yieldcrv3 hours ago
and the bourgeoisie, a temporary regulation would be needed in those areas of the world to separate the upper class from the capability of the rulers
in western nations where that’s not possible, I could see national bans, but one weak link globally and everyone wealthy will get their treatment there
SOLAR_FIELDS3 hours ago
The world of Altered Carbon seems more and more possible every day.
Bluestein2 hours ago
My goodness, what a show that was.-
cleman hour ago
I heard they based a book on it.
walterbellan hour ago
Co-produced by David Ellison and James Vanderbilt.
Loughla2 hours ago
An undying trillionaire class definitely sounds like a possible future. Not an ideal one, mind you, but definitely in the realm of possibilities.
I'm calling it now, Qatar will be the place that allows these treatments once they're a real thing.
I have to imagine the Uber wealthy are pouring money into youthful longevity science.
selimthegrim2 hours ago
The Island of Dr. Ellison
lilycarranza9992 hours ago
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lilycarranza9992 hours ago
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sgnelson2 hours ago
My nightmare is that we solve aging just in time for the Baby Boomers to live forever.
dang44 minutes ago
Please keep generational flamewar off HN.
plutomeetsyouan hour ago
not if every other generation also lives long enough to become the baby boomers.
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black_132 hours ago
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m4633 hours ago
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someothherguyy2 hours ago
m463an hour ago
awesome, thanks!
lilycarranza9992 hours ago
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yieldcrv3 hours ago
I’m on a ton of lists and I still have tsa pre and global entry
OJFord3 hours ago
Interesting flex, is that a metric or an American tonne?
yieldcrv2 hours ago
there’s enough context to guess