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bookofjoe
Loss of cell identity drives human aging: Two new papers erictopol.substack.com

dyauspitr38 minutes ago

So chronic stress is one of the main contributors to aging. I hope I make it to my 40s.

Do we currently have the ability to do targeted methylation or de methylation at sites in cells?

SlightlyLeftPad26 minutes ago

Good news! Research shows that hope reduces stress! [0]

[0]: https://www.forbes.com/sites/tracybrower/2024/09/15/how-bein...

whh5 minutes ago

Sometimes I like to close my eyes and dream of electric sheep.

amelius11 minutes ago

Sadly, AI just made many of us lose all hope.

dyauspitr14 minutes ago

What about Xanax or medication. Hypothetically ignoring the ill effects of the drugs themselves will chemical stress relief have the same anti-aging benefits?

nradov6 minutes ago

If you believe that HRV is inversely correlated with stress then Xanax has the opposite of your intended effect.

Chance-Device20 minutes ago

I suspect that epigenetic aging is adaptive; a deliberately programmed sequence wherein genes more likely to contribute to age-related mortality are shut down progressively. This being in response to random genetic damage accumulating at a predictable rate.

What we think of as aging then becomes primarily the epigenetic response to the problem of DNA damage, much like the symptoms of a virus are mostly the result of the immune response rather than the virus’s direct effects.

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