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>some nights I will just wake up in the middle of the night and won't be able to get back to sleep, then it's when I feel creatine helps

I suspect creatine is responsible for me not being able to get back to sleep easily, because once I'm awake, I'm awake.

You mentioned that you took up CrossFit after starting creatine. Did your previous fit phases include lifting heavy weights?

If your body requires more creatine than your diet currently provides, then supplementing with creatine would help, even without exercising.

from https://pubmed.ncbi.nlm.nih.gov/42578920/ (CrM is creatine monohydrate)

  Results: CrM supplementation without exercise training and diet intervention increased lean tissue mass, strength, and muscular endurance while promoting favorable changes in selected blood lipids, HbA1c, and selected markers of cognitive function and memory. Creatine supplementation during an exercise and weight-loss diet intervention increased lean tissue mass, promoted a greater reduction in body fat percentage, and improved muscular strength, endurance, and selected markers of cognitive function and memory. Supplementation was well-tolerated.

  Conclusion: CrM supplementation with and without exercise and diet intervention may help middle-aged and older adults maintain muscle mass and strength while favourably affecting selected markers of health and cognitive function. Individual cognitive and biomarker findings should be interpreted as exploratory.

Going from minimal exercise to light-moderate exercise will do as much for you as creatine would. To me it's almost a no-brainer to try doing both.

For me, just creatine doesn’t seem to do a whole lot. But heavy workouts (with or without creatine), energize me enormously.

You can do the workout and skip creatine and its marginal benefits pushed by gym bros and health influencers beyond reason.

If you would, please explain or point me to the material where you get your higher dosage recommendation. (I always heard and understood proper dosage to be 5–7.5g/day, 10g/day at the most. I’d like to correct my error if I’m mistaken.)

Yeah I definitely don’t take that much.

The studies I've seen from HCl claim it's more bioavailable too, so you only need 1/3 the dosage compared to honohydrate. That makes the cost pretty comparable.

But otherwise, I'd agree that monohydrate has significantly more research behind it and I'd default to that if it's tolerable.

height?

He did say it's a cycle after all! Scnr

Title:

> Creatine promotes cancer metastasis through activation of Smad2/3

Tldr is basically that creatine helps body cells (in rats) to grow. Regardless wherever they're bad (cancer) or good (muscle). At least that's how I understood that study the last time I came across it. So probably stop using creatine when you've a cancer that's growing. Or its liable to use the creatine to turbocharge it's growth

No comment on the joint thing.

As far as tendons are concerned, they require proactive rehab and you have to load them. There are various loading strategies that a physio is best placed to advise on. Shockwave therapy has also been found to help.

Some pain during tendon loading during rehab is generally expected and not necessarily a negative sign, somewhere around a 4/10 at most.

Recovery is slow in the order of months, not weeks.

There is some evidence that taking a collagen peptide based protein along with vitamin c an hour before loading the tendon can help.

As it's relevant to the sport I practice and just came back from armwrestling training I'd like to randomly comment: Armwrestling clubs have a LOT of people with tendon pain and injuries. The general approach to recovery and building tendon strength (beside lifting heavy) is to do static holds of 10 seconds+ of light to medium weight. Often paired with very large sets (50+ reps) of _extremely light_ weight; lifting almost nothing, just to get the blood through the tendon. You should not feel sore at all in either movement. The idea being that blood gets into tendons through movement. As for static holds; tendons expand during these static holds, so the idea is that they can then absorb more nutrients... Or something like that; I'm no expert by any means!

In the bouldering community there has also been a bit of an uproar where Emil Abrahammsson (find it on Youtube) did very light static holds 2+ times per day for ~30 seconds if I recall correctly for great tendon strength, this also had some influence on how people train for armwrestling. This style was nicknamed "Abrahangs".

Use compression sleeves if you mean knees / elbows. If you mean rotator cuff, do face pulls. This isn't medical advice, just speaking from experience.

I doubt it, it's not the area where creatine is helpful. It'll influence energy provision which helps your muscles recover, and even be a bit stronger in general. I'm in my 45's but I don't experience tendon or joint pain while lifting (my numbers are not going to impress anybody though, but I do train pretty hard). Were I in your shoes I'd take a trip to the GP to try and find out what the source of your pain is. I am tempted to say I would also start taking creatine, but not if you're increasing your load as a result.

Except for old injuries that never completely healed, you should not be suffering joint pain at your age. For starters, you likely should shift to lighter weights.

A general rule is that, after 26, any muscle or joint injury you suffer will never completely heal. So

- avoid injury scrupulously. Don't accept gym challenges (even your own). Be wary of odd exercises, machines, routines. Don't do anything hard at first, always start easy. Be lazy, build up and take your time: you have the rest of your life. Don't work out while under the influence of alcohol, especially when with friends. I avoid certain sports, e.g., any martial arts, soccer, football, even baseball, b/c the variety of situations(and consequent accidents) is so unpredictable as to be uncontrollable. Sprinting, hurdles, gymnastics and high jump are risky too.

- avoid over-stressing muscles and joints. Keep the cardio up - maybe try the gym classes with music (the crowd is better-looking and friendlier).

- See a doctor if you suffer pain unduly.

- Avoid all toe-lift weight machines and weight sleds (sleds that you push as if pushing a truck) like the plague. Never use them, otherwise you may experience pain so severe it will change your "fight or flee" response to 100% "fight" even in a life-threatening situation. Do NOT challenge this suggestion especially if above the age of 40. Explanation: look up the term "plantar fasciitis".

I anticipate "someday soon" cures for tendon/joint pain but I've been waiting too long to expect their arrival before I die!

Isometric holds. Tendons grow slow and recover slow, generally not as much circulation as muscle.

Big heavy holds will help encourage blood flow without stretching them / stressing them as hard as big lifts.

It seems weird because it goes again ROM ideas, but it has definitely helped protect my arms for rock climbing as well as less fatigue in my legs for big lifts.

I'm going to get yelled at, but eat bacon. Fat is good for tendons. Obviously don't eat immense amounts, but if you're eating none, try eatong a couple of slices on workout days.

20g is a loading dose (typically for a week), then it's 3-5g daily for maintenance. But I've seen studies that 5g daily catches up to the 20g loading dose after about a month.

I thought it was too, then I started learning about how so many studies about Creatine were only in the body, and not the brain..

And then there were the discoveries of creatine in the brain in studies.

Your own link shows that what is considered toxic levels are far higher than most people would expect. Vitamin D toxicity is not that easy to accidentally hit.

Overdose has been observed at 1,925 μg/d (77,000 IU per day). Acute overdose requires between 15,000 μg/d (600,000 IU per day) and 42,000 μg/d (1,680,000 IU per day) over several days to months.

And, if you drink a glass of carrot juice a day, you'll receive toxic levels of vitamin A!

~40% of people don't get enough vitamin D [1]. It's not useful to categorize it as some trend, based on people just not following general recommended dosing (with more precise dosing depending entirely on personal sun exposure and skin color).

edit: As an office worker, I take 10k IU per day when I'm entirely indoors (most of the time), but vary it based on sun exposure. I based this on recent studies, and have my doctors approval with an exactly center-of-the-nominal-range vitamin D serum level.

[1] https://pmc.ncbi.nlm.nih.gov/articles/PMC9573946/

My doctor added vitamin D test to his patients recurring blood work since the start of COVID, and found out just about all his patients was deficient or near it.

If you don't have a primarily fish based diet or spend hours under direct overhead sunlight every day without a shirt on, you're probably deficient as well.

I've also heard about it 'hardening' in the bloodstream and that you should really be taking it with K2 as well. This is anecdotal so someone please do more research than basing anything from this comment

Can we really call it a drug when it's something the body synthesizes for regular function?

Yeah, of course I tried to drink more water. I also tried to ramp up the dose slower.

But the cramps are really debilitating, as in random back muscle locks up debilitating, so I thought it best to just give up on this.

How much water can 3g of creatine bind to? Is it like orbeez?

That would be an argument against trying a different source

Your body can synthesize creatine, so it's not essential, but meat is a source of exogenous creatine and eating it results in higher stored creatine levels, which is slightly good for muscle power endurance in the ~5-15 second effort range. Supplementing produces slightly higher relative improvements in creatine levels in vegetarians and vegans than it does in people who eat meat.

Because they lack all kinds of substances that meateaters get plenty of.

Nobody gets fired for supplementing vegans.

Because meat is the best source of creatine from diet.

Well, if vegetarians and those of the Vegan religion don't get enough creatine it is most likely related to them not partaking of an important source of the substance: meat.

Not vouching for creatine, but in general, humans get some vital nutrients from animal consumption. Vegans have to take some B-vitamins for best health due to what they don't get from meat. I assume creatine is the same.

Interesting, I wonder how that is related? Do you believe you are getting hearing loss because you are retaining more water, or because you are dehydrated from retaining more water elsewhere in the body with the same intake rate? Does this go away if you were taking creatine and drinking more water? Or does it come up if you simply drink more water?

That and everyone should be taking a statin.

Any reason someone at a healthy BMI should take GLP-1?