chasila year ago
Are we talking about autophagy?
https://en.m.wikipedia.org/wiki/Autophagy
This makes it sound like apoptosis.
dualogya year ago
Article talks plenty about autophages though..
Jeff_Browna year ago
What are the "Important implications for sports training" mentioned in the article? Should I change how I train?
moi2388a year ago
“ We now know what intensity level of strength training it takes to activate the BAG3 system, so we can optimize training programs for top athletes and help physical therapy patients build muscle better”
So.. what level would that be?
dualogya year ago
Haven't read it yet, but PDF seems to be here:
https://www.cell.com/current-biology/pdf/S0960-9822(24)01027...
austinjpa year ago
From skimming the article and papers it references, the suggestion is that the higher the intensity (which seems to be rate of contraction of skeletal muscle rather than heart rate or respiration rate etc) the stronger the effect.
However, this assumption seems based on mouse experiments.
So, as ever, it's a case of 'watch this space'.
austinjpa year ago
Referenced paper at [0] has annoying copy-paste protection. Key aspects of mouse exercise considered "maximal contractions" are:
Anaesthetised mice.
Electro stimulus of sciatic nerve to induce contractions.
10 sets of 6 contractions, each contraction sustained for 3 seconds, 10 seconds rest after each contraction (rest between sets not described).
Mice allowed to recover in a cage with water but without any food, this is thought to progressively increase activation of mTOR signalling.
Result: hench mice.
[0] https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP27...
unsupp0rteda year ago
No humans are doing 10 sets of anything in the gym, right?
Standard seems to be 3~5 sets?
harimau777a year ago
They aren't identical to just doing 10 regular sets, but perhaps something like pyramid sets or circuit training would be similar enough to produce the same effect?
8474_sa year ago
Try chewing some chocolate between sets.
SeanKilleena year ago
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