chasil4 months ago
Are we talking about autophagy?
https://en.m.wikipedia.org/wiki/Autophagy
This makes it sound like apoptosis.
dualogy4 months ago
Article talks plenty about autophages though..
Jeff_Brown4 months ago
What are the "Important implications for sports training" mentioned in the article? Should I change how I train?
moi23884 months ago
“ We now know what intensity level of strength training it takes to activate the BAG3 system, so we can optimize training programs for top athletes and help physical therapy patients build muscle better”
So.. what level would that be?
dualogy4 months ago
Haven't read it yet, but PDF seems to be here:
https://www.cell.com/current-biology/pdf/S0960-9822(24)01027...
austinjp4 months ago
From skimming the article and papers it references, the suggestion is that the higher the intensity (which seems to be rate of contraction of skeletal muscle rather than heart rate or respiration rate etc) the stronger the effect.
However, this assumption seems based on mouse experiments.
So, as ever, it's a case of 'watch this space'.
austinjp4 months ago
Referenced paper at [0] has annoying copy-paste protection. Key aspects of mouse exercise considered "maximal contractions" are:
Anaesthetised mice.
Electro stimulus of sciatic nerve to induce contractions.
10 sets of 6 contractions, each contraction sustained for 3 seconds, 10 seconds rest after each contraction (rest between sets not described).
Mice allowed to recover in a cage with water but without any food, this is thought to progressively increase activation of mTOR signalling.
Result: hench mice.
[0] https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP27...
unsupp0rted4 months ago
No humans are doing 10 sets of anything in the gym, right?
Standard seems to be 3~5 sets?
harimau7774 months ago
They aren't identical to just doing 10 regular sets, but perhaps something like pyramid sets or circuit training would be similar enough to produce the same effect?
8474_s4 months ago
Try chewing some chocolate between sets.
SeanKilleen4 months ago
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